As a research corresponding to “How to make”, we are studying and developing the organic synthesis design system for new synthetic routes. We have developed the novel system which can create the original synthetic routes and guarantee the practicality of the routes. By inputting a structure of compound into this system, various candidates of synthetic routes are automatically suggested with departure materials and reaction conditions. For each synthetic route, practicality is inspected with knowledge base. We have also discovered the novel method to automatically induce knowledge base from reaction database. The results of this study are highly evaluated in academic meetings all over the world. Also the technology of this study was partially moved to Fujitsu, and this system is on sale as a practical system inside and outside the country from October 2003. Lower right figure is an example of screenshot of the organic synthesis design system.